abstract：BACKGROUND:The prognostic value of the acute phase protein Pentraxin 3 (PTX-3) is not well evaluated in patients with septic shock, which reveal an unacceptably high short- and long-term mortality. New Sepsis-3 definitions are not yet implemented in most biomarker studies. Therefore, this study assesses the prognostic ...

journal_title：Clinical laboratory

authors： Hamed S,Behnes M,Pauly D,Lepiorz D,Barre M,Becher T,Lang S,Akin I,Borggrefe M,Bertsch T,Hoffmann U

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:The usefulness of serum markers for predicting liver necroinflammation is limited in chronic hepatitis B (CHB) patients with normal or slightly elevated alanine aminotransferase (ALT). Monocyte chemoattractant protein-1 (MCP-1) is an important inflammatory mediator in liver disease. Our study was to investig...

journal_title：Clinical laboratory

authors： Fan Y,Wang L,Dou X

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Urine is a good alternative body fluid for gonadotropin studies. There was limited information about the effects of different storage conditions on urinary gonadotropin measurement by using immunochemiluminometric assay (ICMA). METHODS:ICMA was used to determine gonadotropin in urine stored under different ...

journal_title：Clinical laboratory

authors： Ma Y,Xu Z,Gu G,Ren F,Jin H,Zhu W

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Coronary artery disease (CAD) is the leading cause of death worldwide. Atherosclerosis, the main underlying cause of CAD, is a progressive inflammatory disease. microRNAs play a substantial role in the inflammatory process and pathogenesis of atherosclerosis. miR-155, a widely studied microRNA, is associated...

journal_title：Clinical laboratory

authors： Moradi N,Fadaei R,Ahmadi R,Kazemian E,Fallah S

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Death domain superfamily are compact structural motifs that play critical roles in many biological processes including inflammation and apoptosis. Due to mediating protein-protein interactions, these death domains have a high tendency to form oligomers and are notoriously difficult to deal with when overexpr...

journal_title：Clinical laboratory

authors： Fang K,Li Y,Yin X,Samad A,Jin T

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Multiple myeloma is characterized by underlying clinical and biological heterogeneity, which translates to variable responses to treatment and outcome. METHODS:To assess the roles of serum free light chain (sFLC) and K/L FLC ratio (rFLC) in the diagnoses and prognoses of multiple myeloma (MM), sFLC levels a...

journal_title：Clinical laboratory

authors： Meddour Y,Rahali MC,Belakehal SE,Ardjoun FZ,Chaib S,Djidjik R

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:miR-221 and miR-222 are homologous miRNAs located in tandem, within 1 kb from each other, on human x chromosome. Recent studies declared that microRNA-222 is aberrantly expressed in various malignancies. The goal of this research was to measure the expression level of has-miR-222-3P and reveal its diagnostic...

journal_title：Clinical laboratory

authors： Amini S,Abak A,Estiar MA,Montazeri V,Abhari A,Sakhinia E

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Long-term chemotherapy reduces the sensitivity of colon cancer cells to chemotherapeutics like vincristine (VCR) and lead to drug resistance, which has become a major barrier for colon cancer treatment. Calcium antagonists are used as clinical tumor multidrug resistance reversal agents to regulate the P-glyc...

journal_title：Clinical laboratory

authors： Wang LM,Zhang MY,Zhu QS,Lu CF,Bai X

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring of vancomycin is very valuable due to the good correlation between trough levels and clinical outcome. Therefore, it is important to accurately determine the concentration of vancomycin in patient plasma for adequate dose-adjustment. The objective of this study was to develop a ne...

journal_title：Clinical laboratory

authors： Yuan G,Liu H,Shaikh AS,Zhang R,Li P,Wang B,Guo R

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Serum and urinary protein electrophoresis play an important role in the identification of monoclonal gammopathy. Recently, capillary electrophoresis (CE) has been adapted in many clinical laboratories because of several advantages such as short turnaround time, automation, and high reproducibility. However, ...

journal_title：Clinical laboratory

authors： Kim S,Yang HS,Lee A,Cho SY

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Procalcitonin (PCT) is a stable biomarker for bacterial infections; however, limited data is available on new trivalent reagents. We evaluated temperature influence on the activity of PCT reagents. METHODS:Using both conventional and trivalent reagents, we measured PCT levels of 30 clinical samples, stored ...

journal_title：Clinical laboratory

authors： Yoshioka N,Deguchi M,Hagiya H,Kagita M,Yukawa S,Hidaka Y,Tomono K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Lesch-Nyhan syndrome (LNS) is a congenital X-linked recessive neurogenetic disorder caused by mutations in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene. The main clinical manifestation includes hyperuricemia, juvenile-onset gouty arthritis, and neurological developmental disorders. Studies ...

journal_title：Clinical laboratory

authors： Huang J,Zhang C,Guo Q,Zhang X,Ma L,Zhan Y,Chen Y

更新日期：2018-01-01 00:00:00

abstract：:Most digestive system tumors have poor prognoses due to the lack of specific biomarkers. Circular RNAs (circRNAs) regulate the expression of genes and play essential roles in digestive system tumorigenesis. Here we review circRNA functions in gastrointestinal tract tumors. CircRNAs are promising biomarkers for clinica...

journal_title：Clinical laboratory

authors： Liu C,Liu N,Cao B,Zhou Z,Yang G,Zhou P

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality that are not accounted for by traditional risk factors alone. Paraoxonase 1 (PON1) and 25-hydroxyvitamin D have been shown to be involved in the pathogenesis of CV diseases. Objective: This study ...

journal_title：Clinical laboratory

authors： Khoja SO,Miedany YE,Iyer AP,Bahlas SM,Balamash KS,Elshal MF

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Nonleukemic myeloid sarcoma (MS) occurs rarely. Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal condition. We report a rare case of nonleukemic MS associated with HLH. METHODS:Hematologic investigation, 18F-FDG PET/CT, bone marrow aspirate and biopsy, and lymph node biopsy were perf...

journal_title：Clinical laboratory

authors： Zhang J,Zeng Y,Zhang X,Lai W,Chen Y,Xiao R

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The pH may impact the concentration of certain urinary parameters, making urine pre-treatment questionable. METHODS:1) Determining the impact of pH in vitro on the urinary concentration of chemistry parameters assayed on Roche Modular analyzers. 2) Evaluating whether concentrations depended on pH in non-pre...

journal_title：Clinical laboratory

authors： Cohen R,Alkouri R,Tostivint I,Djiavoudine S,Mestari F,Dever S,Atlan G,Devilliers C,Imbert-Bismut F,Bonnefont-Rousselot D,Monneret D

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The balance between collagenolysis and its inhibition is critical during extracellular matrix remodeling in head and neck squamous cell carcinoma (HNSCC). An imbalance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) plays a critical role in the development of tumor cell invasion ...

journal_title：Clinical laboratory

authors： Stanciu AE,Zamfir-Chiru-Anton A,Stanciu MM,Popescu CR,Gheorghe DC

更新日期：2017-10-01 00:00:00

abstract：:Alveolar rhabdomyosarcoma (ARMS) commonly occurring in children and adolescents, is a rare and aggressive soft tissue malignancy. Here, a rare case of pleural ARMS is reported in a boy presenting dyspnea for two weeks. The pathology of a biopsy specimen from pleura showed ARMS. PAX3-FKHR fusion protein is positive and...

journal_title：Clinical laboratory

authors： Lu H,Qin J,Wang Z

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Whole exome sequencing (WES) is one of the most valuable tools for the detection of Mendelian diseases in clinical laboratory. We performed WES for a family of 46,XY disorders of gender development and compared the applicability of public databases for the subsequent phenotype studies of WES-identified mutat...

journal_title：Clinical laboratory

authors： Wang Z,Zhou Y,Yang R,Xia Z,Zeng H,Du L,Ren J,Guo Q

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Effective methods of preventing and treating duodenal carcinoma, especially cancer induced by obesity (resulting from a high-fat diet) remains a longstanding challenge in medicine. METHODS:With regard to the objective, key genes were explored in the evolutional process in a group of normal, obese (high-fat ...

journal_title：Clinical laboratory

authors： Zheng L,Bai J,Zhang JL,Meng X,Hao YN

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The long non-coding RNAs (lncRNAs) are significantly altered in an expanding list of malignant neoplasms, suggesting that they might be popularized as potential biomarkers for cancer detection. This study sought to validate the diagnostic efficacy of lncRNA expression signature(s) as potential biomarker(s) f...

journal_title：Clinical laboratory

authors： Yang H,Han Y,Wu L,Wu C

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Malondialdehyde low-density lipoprotein (MDA-LDL) is a major form of oxidized LDL and considered to be more atherogenic than LDL. Information on major determinants of MDA-LDL and their association in subjects who are not under treatment for diabetes mellitus and dyslipidemia is limited. METHODS:This study i...

journal_title：Clinical laboratory

authors： Moriyama K,Takahashi E

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Recent studies show that alternatively activated macrophages (AAMs) are involved in tissue remodeling and fibrosis. However, the relationship between AAMs and the development of benign prostate hyperplasia (BPH) is unclear. The aim of this study is to investigate the correlation among AAMs, prostate volume, ...

journal_title：Clinical laboratory

authors： Hu W,Liu W,Yu F,Wu Y,Fang X,Hao W

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The adverse effects of exposure to second-hand cigarette smoke on glucose and lipid parameters in women and the underlying mechanisms are not well understood. In this prospective community-based study, we examined the effects of passive smoking on glycemic parameters and lipid profiles in a Chinese female po...

journal_title：Clinical laboratory

authors： Gu L,Li J,Pan G,Zhou X,Zhang J,Lai X,Liu J

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Human T-cell lymphotropic virus type 1 and 2 (HTLV-1/2) immunoassays are used for blood screen- ing from blood products, milk, and organ donors. METHODS:We assessed the performance of the DiaSorin Liaison® XL murex recHTLV-I/II immunoassay relative to the Abbott Architect® rHTLV-I/II immunoassay and with th...

journal_title：Clinical laboratory

authors： Gantner P,Velay A,Guigue N,Barth H,Wendling MJ,Delaugerre C,Fafi-Kremer S

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:FLT3-ITD mutations are common in AML subgroups, particularly in Acute Promyelocytic Leukemia (APL). It infers poor prognosis in AML patients; however, its prognostic value in APL is still controversial. We aimed to assess the distribution and prognostic value of FLT3-ITD mutation within AML subgroups, focusi...

journal_title：Clinical laboratory

authors： Adnan-Awad S,Gaber O,Eltokhy SA,Mourad D,Amer M,Kandeel EZ,Eldesouky I

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Leakage of components from endodontic materials (EM) can occur in case of apical extrusion into the periapical tissue. Therefore, an important prerequisite, besides the mechanical properties of the EM, is a high biocompatibility. In the present study, we elucidated the genotoxic potential of EMs of different...

journal_title：Clinical laboratory

authors： Taubmann A,Willershausen B,Erbe C,Kaina B,Willershausen I

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a powerful technique for the rapid identification of bacteria from growing colonies in routine cultures. In this study, we evaluated the feasibility of a 5-hour incubation on solid medium after sub-cultivation of p...

journal_title：Clinical laboratory

authors： Sekercioglu AO,Cekin Y,Ogunc D,Ongut G,Baysan BO,Colak D,Gunseren F,Donmez L

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Methylene tetrahydrofolate reductase (MTHFR) is the key enzyme of folic acid metabolism and the C677T mutation is associated with decreased enzyme activity. Several studies have shown its regulatory role in carcinogenesis and tumor growth. HBV (hepatitis B virus)-related HCC (hepatocellular carcinoma) is one...

journal_title：Clinical laboratory

authors： Qiao K,Zhang S,Trieu C,Dai Q,Huo Z,Du Y,Lu W,Hou W

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:High level of serum tumor abnormal protein (TAP) may be useful in early diagnosis of cancers. This study aims to investigate the diagnostic value of TAP in patients with papillary thyroid carcinoma (PTC). METHODS:Abnormal sugar chain glycoproteins from peripheral blood of 139 patients with PTC, 39 patients ...

journal_title：Clinical laboratory

authors： Liu Z,Cai J,Yu Y,Fang H,Si Y,Jankee JJ,Shen M

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the association of ACE, angiotensinogen (AGT) and angiotensin II receptor type I (AGTR1) polymorphisms with diabetic nephropathy (DN) in Tunisians. METHODS:The study population comprised 236 type 2 diabetic patients: with nephropathy (DN = 47) and without nephropathy (D...

journal_title：Clinical laboratory

authors： Moussa A,Triki S,Hamdouni H,Fekih O,Ajmi M,hajMbarek IB,Koubaa A,Neffati F,Omezzine A,Najjar MF,Bouslama A

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is considered a chronic gastrointestinal inflammatory disease with unknown etiology. Oxidative stress has been demonstrated to play a critical role in the pathophysiology of IBD. We aimed to investigate the effect of the ischemia-modified albumin (IMA) and CRP levels on the p...

journal_title：Clinical laboratory

authors： Guntas G,Sahin A,Duran S,Kahraman R,Duran I,Sonmez C,Calhan T,Sokmen HM

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Hsa-mir-92a acts as an onco-miRNA and may contribute to the progression and invasion of cervical cancer, which is a common malignant tumor in women worldwide. The objective of the present study was to evaluate whether serum hsa-mir-92a could serve as a diagnostic biomarker for cervical cancer patients. METH...

journal_title：Clinical laboratory

authors： Kong Q,Tang Z,Xiang F,Jiang J,Yue H,Wu R,Kang X

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Deficiency of phenylalanine hydroxylase (PAH) enzyme and elevation of phenylalanine in body fluids cause phenylketonuria (PKU). The gold standard for confirming PKU and PAH deficiency is detecting causal mutations by direct sequencing of the coding exons and splicing involved sequences of the PAH gene. Furth...

journal_title：Clinical laboratory

authors： Dehghanian F,Silawi M,Tabei SM

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Recent reports showed BCL11A may be causatively involved in myeloid leukemia. This study investigated the relationship between BCL11A expression levels and adult acute myeloid leukemia patient characteristics as well as clinical outcomes. METHODS:RT-PCR was employed to detect BCL11A gene expression levels i...

journal_title：Clinical laboratory

authors： Dong H,Shi P,Zhou Y,Yu Y,Guo X,Yao Y,Liu P,Xu B

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:This national survey was initiated to investigate the current status of quality control practice of prenatal screening by statistical analysis of the previous half year data of prenatal screening in 2015. METHODS:Data were sent to all Chinese prenatal screening centers via the National Quality Assessment Sc...

journal_title：Clinical laboratory

authors： He F,Wang W,Zhong K,Yuan S,Wang Z

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The target substances of biomacromolecules are primarily unstable in biological, chemical, and immunological activity, whereby, the standardized substances are obtained with considerable difficulty. We explored the possibility of using a mixed serum sample as a natural reference material for measurement of b...

journal_title：Clinical laboratory

authors： Guang Y,Feng D,Yuzhong L,Hui L

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The primary aim of this study is to measure the JAK-STAT signaling in HBV infected peripheral blood mononuclear cells (PBMCs) stimulated by IFN-α and 3-TC and explore the influence of HBV to the JAKSTAT signaling pathways. METHODS:PBMCs were separated from healthy volunteers and patients who had not receive...

journal_title：Clinical laboratory

authors： Zhang H,Guan ZS,Guan SH,Yang K,Pan Y,Wu YY,Wang AH,Sun BB,Hou J,Mu XX,Gao YF,Cheng WS

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:This study aimed to investigate the role of hyperuricemia in the development of histopathological changes in HSPN. METHODS:Clinical and laboratory data pertaining to 139 adult HSPN patients with and without elevated serum uric acid levels were retrospectively evaluated. There was a 14.4% prevalence of hyper...

journal_title：Clinical laboratory

authors： Lu S,Liu D,Xiao J,Cheng G,Wang X,Zhang X,Yuan W,Dou Y,Liu Z,Zhao Z

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:microRNAs are widely involved in a variety of life processes and considered as potential biomarkers of tumor prognosis. A growing number of studies have documented that miRNAs were associated with outcome in NSCLC patients and can act as a prognostic marker. However, existing studies concerning the relations...

journal_title：Clinical laboratory

authors： Zhan B,Lu D,Luo P,Wang B

更新日期：2016-11-01 00:00:00